Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :AG 18118409-57-7HY-1186.17C10H6N2O2>98%Solubility:DMSOMechanisms: Pathways:JAK/STAT Signaling; Target:EGFR Pathways:Protein Tyrosine Kinase/RTK; Target:EGFR Biological Activity:AG18(RG50810; Tyrphostin A23) inhibits EGFR with IC50 of 40 AG-18(RG-50810;TyrphostinA23)inhibitsEGFRwithIC50of40μM.M IC50 Value: 40 uM (inhibition of EGFR autophosphorylation)[1] Target: EGFR AG-18 (Tyrphostin A23) are inhibitors of tyrosine kinases and function by binding to the active sitesof the enzymes. Molecular modeling of tyrphostin A23 into the tyrosine-binding pocket in mu2provides a structural explanation for A23 being able to inhibit the interaction between YXXPhi motifsand mu2. in vitro: A23 inhibited the internalization of (125)I-transferrin in Heb7a cells without having anydiscernible effect on the morphology of compartments of the endocytic pathway. Control tyrphostins,active as inhibitors of tyrosine kinase activity, but incapable of inhibiting the YXXPhi motif/mu2interaction, did not inhibit endocytosis [2]. Tyrphostin A23 inhibits Tfn internalization andredistributes most of hTfR to the plas...References:[1]. Lyall RM, Zilberstein A, Gazit A, Tyrphostins inhibit epidermal growth factor (EGF)-receptortyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J Biol Chem. 19 Aug25;2(24):14503-9.25;2(24):145039. [2]. Banbury DN, Oakley JD, Sessions RB, Tyrphostin A23 inhibits internalization of the transferrinreceptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of theAP-2 adaptor complex. J Biol Chem. 2003 Apr 4;278(14):12022-8. [3]. Ortiz-Zapater E, Soriano-Ortega E, Marcote MJ, Trafficking of the human transferrin receptor inplant cells: effects of tyrphostin A23 and brefeldin A. Plant J. 2006 Dec;48(5):757-70. [4]. Ogura T, Imanishi S, Shibamoto T. Activation of background membrane conductance by thetyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pigventricular...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 080,USAess.com Web: www.medchemexpress.com9 Email: info@medchemexpr
