FORMULATION OF DUAL CYCLOXYGENASE (COX) AND LIPOXY

专利名称：FORMULATION OF DUAL CYCLOXYGENASE

(COX) AND LIPOXYGENASE (LOX)INHIBITORS FOR MAMMAL SKIN CARE

发明人：JIA, Qi申请号：EP04758816.5申请日：20040402公开号：EP1631304A1公开日：20060308

摘要：The present invention provides a novel composition of matter comprised of amixture of two specific classes of compounds-Free-B-Ring flavonoids and flavans-for usein the prevention and treatment of diseases and conditions associated with the skin. Thiscomposition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase(LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. Thisinvention further provides a method for the prevention and treatment of diseases andconditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX). Themethod for preventing and treating COX and LOX mediated diseases and conditions ofthe skin is comprised of topically administering to a host in need thereof a

therapeutically effective amount of a composition comprising a mixture of Free-B-Ringflavonoids and flavans synthesized and/or isolated from a single plant or multiple plants,preferably in the Scutellaria and Acacia genus of plants and pharmaceutically and/orcosmetically acceptable carriers. Finally the present invention provides a method for theprevention and treatment of COX and LOX mediated diseases and conditions, includingbut not limited to sun burns, thermal burns, acne, topical wounds, minor inflammatory

conditions caused by fungal, microbial and viral infections, vitilago, systemic lupuserythromatosus, psoriasis, carcinoma, melanoma, as well as other mammal skin cancers,skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, windand dry environments, wrinkles, saggy skin, lines and dark circles around the eyes,dermatitis and other allergy related conditions of the skin. Use of the compositiondescribed herein also affords the benefit of smooth and youthful skin with improvedelasticity, reduced and delayed aging, enhanced youthful appearance and texture, andincreased flexibility, firmness, smoothness and suppleness.

申请人：Unigen Pharmaceuticals, Inc.

地址：2660 Willamette Drive, N.E. Lacey, Washington 98516 US

国籍：US

代理机构：Pohlman, Sandra M.

更多信息请下载全文后查看