System and Method For the Heterologous Expression

专利名称：System and Method For the Heterologous

Expression of Polyketide Synthase GeneClusters

发明人：Christopher N. Boddy,Anthony Garza申请号：US12565314申请日：20090923

公开号：US20100184038A1公开日：20100722

摘要：A system and method for heterologous expression of polyketide biosyntheticpathways from streptomycetes hosts in for the production and discovery of secondarymetabolites. Genomic DNA from encoding the oxytetracycline biosynthetic pathway isinserted into the genome of the surrogate host . The transcriptional machineryrecognizes and uses the streptomycetes promoter regions to express the biosyntheticenzymes. Co-expression in of oxytetracycline biosythensis enzymes and , a key piece ofthe transcriptional machinery, enables to recognize and use the promoters from theoxytetracycline biosynthetic pathway, facilitating production of oxytetracycline.

申请人：Christopher N. Boddy,Anthony Garza

地址：Ottawa CA,Syracuse NY US

国籍：CA,US

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