Adrafinil_DataSheet_MedChemExpress

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Data Sheet

Product Name:Cat. No.:CAS No.:

Molecular Formula:Molecular Weight:Target:Pathway:Solubility:

AdrafinilHY-179637-13-7C15H15NO3S2.35

Adrenergic ReceptorGPCR/G Protein10 mM in DMSO

BIOLOGICAL ACTIVITY: 

Adrafinil (CRL–40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessivesleepiness and inattention, Adrafinil is believed to serve as an alpha–1 adrenoceptor agonist.IC50 value:Target:in vitro:

in vivo: CRL 40028 antagonizes prazosin–induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect ofCRL 40028 in the quaking mouse [1]. Adrafinil in rat serum was stable over three freeze–thaw cycles at ambient temperature for 6 h.The method had a lower limit of quantitation of 16.5 ng/ml, which offered high sensitivity for the determination of adrafinil in serum[2]. Aged beagle dogs were trained on either a size or intensity discrimination task 2 h following treatment with either 20 mg/kg ofadrafinil or a placebo control. Treatment with adrafinil produced significant improvement in learning, as indicated by a decrease inboth errors and trials to criterion. An effect of adrafinil on motivation may partially account for these findings; however, adrafinil didnot significantly affect response latency. Adrafinil is believed to serve as an alpha–1 adrenoceptor agonist [3].

References:

[1]. Simon P, et al. Pharmacological evidence of the stimulation of central alpha–adrenergic receptors. Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2–3):183–6.

[2]. Rao RN, et al. LC–ESI–MS determination and pharmacokinetics of adrafinil in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873(1):119–23.

[3]. Milgram NW, et al. Oral administration of adrafinil improves discrimination learning in aged beagle dogs. Pharmacol Biochem Behav. 2000 Jun;66(2):301–5.

Caution: Product has not been fully validated for medical applications. For research use only.

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